Understanding Resistance to Immunotherapy in Cholangiocarcinoma

Understanding Resistance to Immunotherapy Cholangiocarcinoma

In recent years, immunotherapy has emerged as a breakthrough therapy for many cancers.  Research has shown that the addition of immunotherapy to standard chemotherapy improves survival for patients with cholangiocarcinoma (CCA).  Although studies showed that approximately one in four patients had a long-term benefit, many patients did not respond to treatment.  The more that is learned about immunotherapy resistance, the more that can be done to improve the quality of medical care for cancer diagnosis and treatment, particularly for patients with CCA.  With support from the Bachrach Family Foundation, the Cholangiocarcinoma Foundation is leading a collaborative, multi-center research grant process to explore and evaluate why some patients’ cancers develop resistance.  Knowledge arising from this work will influence clinical trial design leading to improved use of immunotherapy, thereby improving patients’ quality of life and leading to accurate individualized treatment.