Targeted Mitochondrial Delivery Systems for Vascular Interventions

The Bin Jiang lab at Northwestern University is working on developing techniques for intercellular mitochondrial transfer.  Mitochondrial dysfunction contributes to many common disorders, including cardiovascular diseases, diabetes, neurodegeneration, and aging, but treatment is currently unavailable to restore mitochondrial function.

Mitochondrial dysfunction underlies various diseases, often with limited treatment options. Replacing damaged mitochondria with healthy counterparts holds promise, yet faces challenges such as specificity, cellular uptake efficiency, and potential loss of function during transfer. The Jiang lab at Northwestern University is dedicated to pioneering Targeted Mitochondrial Delivery Systems (MDS) for vascular interventions. This research strives to surmount translational barriers in mitochondrial transfer technology known for its potential in rescuing damaged cells and tissues. Successful completion of this study will not only contribute to the advancement of mitochondria-based therapeutics but also holds broader implications for diseases involving mitochondrial dysfunction.